As. Pac. J. Mol. Biol. & Biotech., April 2012 Vol. 2, 45-54
Review : The What, Where, and How of Resolvins
Shivani Dwivedi*, Sapan Patel and Kapil Jain
Department of Periodontics, People's College of Dental Sciences, Bhopal, Madhya Pradesh, India
* Author for correspondence: Shivani Dwivedi
Department of Periodontics, People's College of Dental Sciences, Bhopal, Madhya Pradesh, India.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Tel.: +919926027068.
Abstract.
Complete resolution of an acute inflammatory response and its return to homeostasis are essential for healthy tissue. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programmes, which enable inflamed tissues to return to homeostasis. The recently uncovered families of endogenous mediators are now gaining attention. This new genus of mediator possesses pro-resolving, anti-inflammatory, and antibiotic as well as host-directed antimicrobial actions. Therefore it seems to promise a novel approach for the treatment of inflammation associated diseases, based on endogenous agonists of resolution. The following review therefore focuses on the basics of resolvins, covering their generation pathway and activity.
