As. Pac. J. Mol. Biol. & Biotech., Apr 2014 Vol. 2, 172-179
Review Reciprocal Regulation of the Periodontitis and Diabetes
Gurmeet Kaur and Adline Princy S*
Quorum Sensing Laboratory, Centre for Research on Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA’s Hub for Research and Innovation (SHRI), SASTRA University, Thanjavur, Tamil Nadu, India.
* Author for correspondence: Associate Professor Dr. Adline Princy S.
Quorum Sensing Laboratory, Centre for Research on Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur – 613 401 Tamil Nadu, India.
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Abstract.
Periodontitis and its association with systemic diseases such as diabetes has been an area of focus recently. Diabetes associated with periodontal pathogens can result in the periodontal tissue damage and hence, resulting in periodontal disease. In the same way, periodontal disease is also involved in the worsening of various systemic diseases through inflammation process. Inflammation due to microbial flora of the oral cavity and infection due to it plays a central role in the development and the interrelation between the two diseases. The inflammatory markers which are responsible for the development of insulin resistance are high in case of patients with periodontitis and thus they are on an edge of developing insulin resistance and further worsening of it. This paper is intended to provide information regarding the role of periodontal disease in systemic diseases and bidirectional relationship between periodontitis and diabetes.
